At a scale of the current global technical industrial complex, considering an expanding human population and increasing per capita needs, it is evident that Earth’s biosphere can no longer sustainably process and absorb man-made technological pollutants. Declining biodiversity in crucial areas, over-reliance on non-renewable natural resources, destruction of once wild eco-systems with subsequent soil erosion, shows the necessity for making an urgent wake-up call for responsible and realistic human intervention. To accomplish that, an increased, deeper understanding of the situation is required. For researchers working on bio-regenerative life support in closed systems, the small scale volumes and quicker cycling times than those that occur in Earth’s biosphere make it clear that comprehensive, renewable, evolving systems must be designed to enable longer term renewal of water, atmosphere, nutrient re-cycling, the production of healthy food, and safe environmental methods of maintaining the technical structure systems. Developing these technical systems- fully incorporated and in balance with living systems reveals approaches that enable us to work together with our larger living systems in a way that facilitates reciprocal maintenance and longevity.